Videos

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1. Important issues in medical research started from the millennium project

Discussion of the impact of Science in Japan caused by the “Millenium Project”, which was initiated by the former Japanese Prime Minister K. Obuchi in 1999 to vitializescience and technology of Japan.

Professor HirooImura, M.D., Ph.D.Foundation for Biomedical Research and Innovation at Kobe, Kyoto University

1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

Discussion on the recent progress in the pathogenesis, diagnosis and treatment of Paroxysmal nocturnal hemoglobinuria (PNH).

Professor Yuzuru KANAKURA, M.D., Ph.D. The Department of Hematology and Oncology, Osaka University Graduate School of Medicine

2. Gene therapy comes of age: focusing on CAR-T cell therapy

Introduction of CD19-targeted CAR-T cell therapy approved by FDA in 2017 and progresses including application of genome editing technology to this novel therapy.

Professor Keiya Ozawa. Emeritus Professor and Visiting Professor Division of Immuno-Gene & Cell Therapy (Takara Bio)Jichi Medical University

2. Understanding of genetic alterations in myeloproliferative neoplasms

Introduction of a research findings of JAK2V617F, CALR, and MPL mutations in patients suspected of Philadelphia-negative myeloproliferative neoplasm (MPN), as well as discussion on surrounding issues.

Professor Norio KOMATSU, M.D., Ph.D. Department of Hematology, Juntendo University School of Medicine

3. On the genetic basis of myelodysplastic syndromes

Summary of major advances of recent years in the ﬁeld of MDS research, focusing on the results of the studies by Prof. Ogawa’s team.

Professor Seishi OGAWA, M.D., Ph.D.,Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University

3. Regulatory T cell: from the past to the present

Presentation of the history of the discovery of Regulatory T cells (Treg cells) along with the history of its function. The latter part of the lecture discusses the possibility of controlling immune response involving Treg cells from physiological and pathological perspectives.

Professor Shimon Sakaguchi, M.D., Ph.D.Immunology Frontier Research Center, Osaka University

4. Antithrombin resistance: a new mechanism of inherited thrombophilia

Introduction of a study investigating a possible causative gene defect in the large Japanese family with inherited thrombophilia, as well as the discovery of a novel missense mutation in the prothombin gene (p.ARG596Leu) resulting in a variant prothrombin.

Professor Tetsuhito KOJIMA, M.D., Ph, D.Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine

4. Cell-based therapy for Parkinson’s disease

Discussion of the current status and prospects of induced pluripotent stem cell (iPSC) based therapy for Parkinson’s Disease.

Professor Jun Takahashi, M.D., Ph.D.Center for iPS Cell Research and Application (CiRA), Kyoto University Department of Clinical Application

5. Progress and vision in the treatment of hemophilia

An overview of the recent progress and vision in the treatment of hemophilia including clinical trials on therapeutic drugs and gene therapy.

Professor Midori SHIMA, M.D., Ph, D.Department of Pediatrics, Nara Medical University

5. Retinal regenerative medicine using iPS cells

Discussion of clinical application of therapies using retinal pigment epithelium (RPE) generated from pluripotent stem cells (embryonic stem cells [ESC], iPSC), and its potential for global pharmaceutical and related businesses.

Project Leader Masayo Takahashi, M.D., Ph.D.Laboratory for Retinal Regeneration RIKEN

1. Important issues in medical research started from the millennium project

Videos

1. Important issues in medical research started from the millennium project

1. Important issues in medical research started from the millennium project

1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

2. Gene therapy comes of age: focusing on CAR-T cell therapy

2. Gene therapy comes of age: focusing on CAR-T cell therapy

2. Understanding of genetic alterations in myeloproliferative neoplasms

2. Understanding of genetic alterations in myeloproliferative neoplasms

3. On the genetic basis of myelodysplastic syndromes

3. On the genetic basis of myelodysplastic syndromes

3. Regulatory T cell: from the past to the present

3. Regulatory T cell: from the past to the present

4. Antithrombin resistance: a new mechanism of inherited thrombophilia

4. Antithrombin resistance: a new mechanism of inherited thrombophilia

4. Cell-based therapy for Parkinson’s disease

4. Cell-based therapy for Parkinson’s disease

5. Progress and vision in the treatment of hemophilia

5. Progress and vision in the treatment of hemophilia

5. Retinal regenerative medicine using iPS cells

5. Retinal regenerative medicine using iPS cells

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